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Cheap bus tickets from San Francisco, CA to Des Moines, IA

from $202.99

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Bus stations and stops in San Francisco, CA

Please note: your ticket will contain the most up-to-date address information.

Discover all destinations

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Frequently asked questions

With FlixBus, you can conveniently reach 51 destinations from Des Moines, including Chicago, Minneapolis, Kansas City.
Yes, night trip options are available from San Francisco to Des Moines. Check out the route's schedule and choose the best option to suit your plans!
Our Real-Time Bus Tracker allows you to track your bus location. Just select the relevant bus stop and check the time of arrival. This way, you can find out where your bus is and check for delays on the route.
The fastest bus from San Francisco to Des Moines takes 50 hours 5 minutes.
The bus journey from San Francisco to Des Moines is 2159 miles. FlixBus can get you there in 50 hours 5 minutes.
The cost of a bus ticket from San Francisco to Des Moines starts at just $202.99.
When purchasing your bus ticket from San Francisco to Des Moines, you can choose your preferred payment method from card, Paypal, Google Pay, and more.
You can book your FlixBus ticket starting at just $202.99. The easiest way to purchase your ticket is on this website or through the app. Book early to get the best price.
FlixBus allows you to bring your bike on board from San Francisco to Des Moines, subject to availability. Check out our prices for bike transport here.

Find the cheapest buses from San Francisco to Des Moines

Getting from San Francisco to Des Moines is cheap and easy when you travel with FlixBus. The two cities are 2159 miles apart and traveling between the two takes as fast as 50 hours 5 minutes.
FlixBus tickets are always good value, but you can save even more money by booking online in advance. Book on the website or our FlixBus App in minutes, then simply use your phone as your ticket to board the bus.
You can get bus tickets to travel between San Francisco and Des Moines for as little as $202.99 if you book in advance and/or outside of busy travel times, like weekends and holidays.

For a quick, easy and environmentally-conscious choice, travel with FlixBus.
We have a large network of destinations, so you can trust us to take you from your desired departure city to your destination in comfort and style - all for great value.

Traveling from San Francisco to Des Moines

It's easy to get from San Francisco to Des Moines with FlixBus, with 4 direct buses per day.
It can take a minimum time of 50 hours 5 minutes.
Bus travel is the most environmentally friendly way to travel long distances and we're working to make it even greener with high environmental standards across our fleet of buses, the use of alternative drive and fuel technologies, and the option for all passengers to offset their carbon emissions at the point of buying a ticket.
The average cost of bus travel between San Francisco and Des Moines is $202.99, which makes bus travel far cheaper than any other method.

Taking the bus from San Francisco

Traveling from San Francisco and not familiar with it? Here's everything you need to know.
San Francisco is a transport hub with 4 bus station(s); the 36 connections departing from San Francisco every day take travelers both within the state and further afield.

Arriving in Des Moines

Traveling to Des Moines for the first time? Here's what you need to know:
Des Moines is very well connected to other destinations on the FlixBus network, with 51 connections arriving in one of the 2 bus station(s) of the city, giving you easy access to all corners of the country.

What to expect onboard the FlixBus bus from San Francisco to Des Moines

Getting from San Francisco to Des Moines aboard a FlixBus bus means traveling in comfort and style, with all the services you need to keep you occupied. Most of our buses include free Wi-Fi onboard, an entertainment system, toilets and power outlets.
You can bring one carry-on and one check-in piece of luggage per passenger, so even if you're taking a long trip, you don't need to worry about traveling light.
All ticket holders are guaranteed a seat on our buses but if you want to reserve a seat, you can do so at the time of booking. Choose from a classic seat, table seat, panorama seat or extra seat.
Just book online or on our FlixBus App when purchasing your ticket using any of our available payment methods.

Onboard services are subject to availability