Cheap bus tickets from Tupelo, MS to Chicago, IL

from $116.99

Traveling during COVID-19

Find all the current information about our network.

Network updates

Our Safety Measures

To make traveling safe and comfortable, we ensure high hygiene standards.

Health & Safety

Satisfied Customers

We've transported 100+ million happy customers worldwide. US customers give us an amazing 4.5 stars.

Read customer reviews

The Green Choice

FlixBus is one of the most eco-friendly ways to travel. Learn more about our sustainability initiatives and carbon offset programs.

Offset emissions for your trips

Bus stations and stops in Tupelo, MS

Please note: your ticket will contain the most up-to-date address information.

Tupelo (M&H Quick Stop)

2611 S Eason Blvd
38804 Tupelo
United States

View this address on Google Maps

Bus stations and stops in Chicago, IL

Please note: your ticket will contain the most up-to-date address information.

Chicago (Downtown)

355 S Canal St
60606 Chicago
United States

View this address on Google Maps

Bus will stop on east side of Canal Street between Van Buren St. and Jackson Blvd, one block south of Union Station. Bus will stop in front of the Divvy bikeshare station and adjacent to the CTA local bus stop.

Chicago 95Th & Dan Ryan

15 W 95Th St
60628 Chicago
United States

View this address on Google Maps

Chicago Amtrak

225 S Canal St
60606 Chicago
United States

View this address on Google Maps

Chicago Bus Station

630 W Harrison St
60607 Chicago
United States

View this address on Google Maps

Chicago Cumberland Ave

5800 N Cumberland Ave
60631 Chicago
United States

View this address on Google Maps

Discover all destinations

Choose from over 80 travel destinations in 11 states and growing!

Tupelo, MS - Chicago, IL: Quick information

Online payment

Yes

Distance

529 miles

Direct connection

Yes

Environmentally-friendly travel?

Yes

Discover more popular bus connections

Onboard services are subject to availability