Skip to main content

Cheap bus tickets from San Ysidro, CA to Chicago, IL

Comfort on board

Our buses are equipped with large and comfortable seats, a toilet, Wi-Fi and power outlets.
Our onboard service

Health and Safety

Keep yourself and others safe while traveling with us.
Learn more

Satisfied Customers

We've transported 100+ million happy customers worldwide. US customers give us an amazing 4.5 stars.
Read customer reviews

The Green Choice

FlixBus is one of the most eco-friendly ways to travel. Learn more about our sustainability initiatives and carbon offset programs.
Offset emissions for your trips

On this page

Bus stations and stops in San Ysidro, CA

Please note: your ticket will contain the most up-to-date address information.

Discover all destinations

Choose from over 80 travel destinations in 11 states and growing!

Frequently asked questions

With FlixBus, you can conveniently reach 102 destinations from Chicago, including Indianapolis, Detroit, Milwaukee.
Yes, night trip options are available from San Ysidro to Chicago. Check out the route's schedule and choose the best option to suit your plans!
Our Real-Time Bus Tracker allows you to track your bus location. Just select the relevant bus stop and check the time of arrival. This way, you can find out where your bus is and check for delays on the route.
The fastest bus from San Ysidro to Chicago takes 50 hours 5 minutes.
The bus journey from San Ysidro to Chicago is 2276 miles. FlixBus can get you there in 50 hours 5 minutes.
When purchasing your bus ticket from San Ysidro to Chicago, you can choose your preferred payment method from card, Paypal, Google Pay, and more.

Find the cheapest buses from San Ysidro to Chicago

Getting from San Ysidro to Chicago is cheap and easy when you travel with FlixBus. The two cities are 2276 miles apart and traveling between the two takes as fast as 50 hours 5 minutes.
FlixBus tickets are always good value, but you can save even more money by booking online in advance. Book on the website or our FlixBus App in minutes, then simply use your phone as your ticket to board the bus.

For a quick, easy and environmentally-conscious choice, travel with FlixBus.
We have a large network of destinations, so you can trust us to take you from your desired departure city to your destination in comfort and style - all for great value.

Taking the bus from San Ysidro

Traveling from San Ysidro and not familiar with it? Here's everything you need to know.
San Ysidro is a transport hub with 2 bus station(s); the 29 connections departing from San Ysidro every day take travelers both within the state and further afield.

Arriving in Chicago

Traveling to Chicago for the first time? Here's what you need to know:
Chicago is very well connected to other destinations on the FlixBus network, with 102 connections arriving in one of the 3 bus station(s) of the city, giving you easy access to all corners of the country.

What to expect onboard the FlixBus bus from San Ysidro to Chicago

Getting from San Ysidro to Chicago aboard a FlixBus bus means traveling in comfort and style, with all the services you need to keep you occupied. Most of our buses include free Wi-Fi onboard, an entertainment system, toilets and power outlets.
You can bring one carry-on and one check-in piece of luggage per passenger, so even if you're taking a long trip, you don't need to worry about traveling light.
All ticket holders are guaranteed a seat on our buses but if you want to reserve a seat, you can do so at the time of booking. Choose from a classic seat, table seat, panorama seat or extra seat.
Just book online or on our FlixBus App when purchasing your ticket using any of our available payment methods.

Onboard services are subject to availability