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Cheap bus tickets from Chicago, IL to San Ysidro, CA

What to expect of your trip

Fast, easy, and affordable options from Chicago, IL to San Ysidro, CA

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Bus stations and stops in Chicago, IL

Please note: your ticket will contain the most up-to-date address information.

Onboard services are subject to availability

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Vehicle passing through a city

Digital ticket & Live tracking

Discover the FlixBus app

Book trips
Your tickets
Track your trip
Always in the know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

The bus route from Chicago to San Ysidro covers 2196 miles. FlixBus can bring you from Chicago to San Ysidro in 49 hours 5 minutes.
Yes! There are 5 rides daily from Chicago to San Ysidro.
You can buy your bus ticket from Chicago to San Ysidro choosing your preferred payment method among card, Paypal, Google Pay, and more!
You can track your bus location on our Real-Time Bus Tracker. Just select the relevant bus stop and check the time of arrival. Find out where your bus is and check if there are delays on the route.
Yes, night trip options are available from Chicago to San Ysidro. Check out the route's schedule and choose the best option to suit your plans!
Yes, weekend trip options are available from Chicago to San Ysidro. Check out the route's schedule and chose the best option to suit your plans!
With FlixBus, you can conveniently reach 32 destinations from San Ysidro, including Los Angeles, Orange County-Anaheim-Santa Ana, Long Beach.

Buses from Chicago to San Ysidro

Find the cheapest buses from Chicago to San Ysidro

It couldn't be easier to book your travel from Chicago to San Ysidro with FlixBus - and when you book in advance, you can save money too! Make your journey even easier with the FlixBus app. All your information will be saved for the next time you travel.

What to expect onboard the FlixBus bus from Chicago to San Ysidro

Traveling from Chicago to San Ysidro is stess-free, clean and comfortable - and it couldn't be easier to book a ticket. You can book online via the website, on our app, in person at a FlixShops or at resellers.
We accept card payment as well as Paypal, Google Pay and Apple Pay, but there are many more payment options that you can choose from. The easiest way to book your ticket is using our app. You'll be able to make your reservation within seconds and there's no need to print and carry the ticket with you, as your phone will be your ticket.

Want to sit beside family or friends or keep the space beside you free? Need easy access to the toilet or a table to get on with some work whilst traveling? You can reserve a seat when you book on the app or website, and you can choose from a variety of seat options. Once you're settled in your seat, you can sit back and relax with plenty of onboard services to help you make the most of your trip. Most of our buses have onboard Wifi so you can catch up on your favorite shows, chat with your friends or listen to music and podcasts. We've also got toilets onboard, as well as power outlets.
What's more, you get a generous luggage allowance when you travel with FlixBus with one carry-on bag and one checked bag, so you can bring everything you need for your trip.