Cheap bus tickets from San Francisco, CA to Key West, FL

Traveling during COVID-19

Find all the current information about our network.

Network updates

Our Safety Measures

To make traveling safe and comfortable, we ensure high hygiene standards.

Health & Safety

Satisfied Customers

We've transported 100+ million happy customers worldwide. US customers give us an amazing 4.5 stars.

Read customer reviews

The Green Choice

FlixBus is one of the most eco-friendly ways to travel. Learn more about our sustainability initiatives and carbon offset programs.

Offset emissions for your trips

Bus stations and stops in San Francisco, CA

Please note: your ticket will contain the most up-to-date address information.

San Francisco (5th/Townsend)

409 Townsend Street
94107 San Francisco
United States

View this address on Google Maps

Bus will board on the south side of the intersection of Townsend St and 5th St. The stop is located at a white curbside designated by a green FlixBus sign. Across the street is the "User Testing" building and several bike racks. Please stay clear of the green bike lane.

Daly City BART Station

500 John Daly Blvd
94014 Daly City
United States

View this address on Google Maps

Bus will board along the loading curb inside parking lot off De Long St (on the SE side of BART tracks on upper level.) From BART, take the bridge across to the parking lot. From the lower-level bus stops, walk up the ramp to the parking lot. For drop off, access the parking lot from De Long St.

San Francisco Bus Station

425 Mission St Ste 206
94105 San Francisco
United States

View this address on Google Maps

San Francisco Fisherman’s Wharf (Hyde/Beach)

700 Beach Street
94109 San Francisco
United States

View this address on Google Maps

Bus will board at the white loading curb on Beach St, immediately west of the Beach St and Hyde St intersection, next to the Hyde St and Beach St Cable Car station.

Bus stations and stops in Key West, FL

Please note: your ticket will contain the most up-to-date address information.

Key West

910 Caroline Street
33040 Key West, FL
United States

View this address on Google Maps

Bus will stop in the tour bus parking lot on Caroline Street, located behind the Old Town Garage.

Key West Bus Station

3439 S Roosevelt Blvd
33040 Key West
United States

View this address on Google Maps

Discover all destinations

Choose from over 80 travel destinations in 11 states and growing!

San Francisco, CA - Key West, FL: Quick information

Online payment

Yes

Distance

2546 miles

Direct connection

Yes

Environmentally-friendly travel?

Yes

Discover more popular bus connections

Onboard services are subject to availability